Click here to find out more information about the Behçet’s Patients Support team.
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I thought our marvellous Behçet’s community would appreciate sight of the following research, all helping to add to the ‘body of knowledge’. Some of the full article confuses me, so don’t let that put you off if you find the same! Certainly, I think it has particular relevance regarding consideration as to the timing of medication, and recording what is ‘going on’ and when; as the summary below mentions.
Insights into how the body clock and time of day influence immune responses are revealed today in a study published in leading international journal Nature Communications. Understanding the effect of the interplay between 24-hour day-night cycles and the immune system may help inform drug-targeting strategies to alleviate autoimmune disease.
[The full article available at nature.com/articles/s41467-…]
Circadian rhythms or 24-hour rhythms are generated by the body clock, allowing us to anticipate and respond to the 24-hour cycle of our planet. Maintaining a good body clock is generally believed to lead to good health for humans, and disrupting the circadian rhythm (for example, working night shifts) has been associated with immune diseases such as multiple sclerosis; however, the underlying molecular links have been unclear.
In the new study, Professor Kingston Mills and Dr Caroline Sutton of Trinity College Dublin, and Dr Annie Curtis of RCSI (Royal College of Surgeons Ireland), and colleagues show that immune responses and regulation of autoimmunity are affected by the time of the day when the immune response is activated.
Using mice as a model organism, they show that a master circadian gene, BMAL1, is responsible for sensing and acting on time-of-the-day cues to suppress inflammation. Loss of BMAL1, or induction of autoimmunity at midday instead of midnight, causes more severe experimental autoimmune encephalomyelitis, which is essentially an analogue of multiple sclerosis in mice.
Professor of Experimental Immunology at Trinity, Kingston Mills, said: “In the year that the Nobel Prize in Medicine was awarded for discoveries on the molecular mechanisms controlling the circadian rhythm, our exciting findings suggest that our immune system is programmed to respond better to infection and insults encountered at different times in the 24-hour clock. This has significant implications for the treatment of immune-mediated diseases and suggests there may be important differences in time of day response to drugs used to treat autoimmune diseases such as multiple sclerosis.”
Although further investigations are needed to understand how to precisely modulate circadian rhythm or time-of-the-day cues for beneficial immunity, the findings in this article serve well to remind us the importance of ‘keeping the time’ when dealing with the immune system.
Research Lecturer in the Department of Molecular and Cellular Therapeutics at RCSI, Dr Annie Curtis, said: “Our study also shows how disruption of our body clocks, which is quite common now given our 24/7 lifestyle and erratic eating and sleeping patterns, may have an impact on autoimmune conditions.”
“We are really beginning to uncover exactly how important our body clocks are for health and wellbeing.”
Behçet’s Syndrome Society
Submit your photo to the EURORDIS Photo Award!
EURORDIS Photo Award
What does it mean for you, your friends, family or the person you care for to live with a rare disease?
The EURORDIS Photo Award is an opportunity to visually express the reality of living with a rare disease and to share your rare disease story.
Submit your photo before 31 January 2018 to be in with a chance of winning the EURORDIS Photo Award 2018.
The Photo Award is one of the 13 EURORDIS Black Pearl Awards presented in recognition of the outstanding achievements and exceptional work of people making a difference for the rare disease community.
The last EURORDIS Photo Contest saw nearly 400 people from 54 different countries around the world submit a photo.
Upload your photo, including a short description of your image and your photo will appear in the gallery.
World-renowned National Geographic photojournalist Marcus Bleasdale will then select a shortlist of 5 photos that will be opened to a public vote.
Vote for your favourite finalist
Online voting for the five finalists will open on 13 February 2018 via blackpearl.eurordis.org/photo-award.
Voting will close and the winner will be announced live at the EURORDIS Black Pearl Awards Ceremony in Brussels on 20 February. The three finalists with the most votes will each receive a prize.
Be part of the action on the night – find out who wins the EURORDIS Photo Award and 12 other Black Pearl Awards on the evening of 20 February by watching a livestream of the Awards Ceremony via blackpearl.eurordis.org/live.
Many people with Behcet’s are finding that Mindfulness is helping them to cope with physical and mental symptoms on a daily basis and it is helps with general wellbeing. See the link to an Introduction to Mindfulness by Jon Kabat Zinn and if you find it interesting and would like to know more, you can watch more of his videos on You Tube.
The minutes of the 2017 AGM and a full report of the Conference are now available.
This new animation from @TheKingsFund shows how the NHS in England works. Watch it here